What disease is known for causing bone deformities due to a disruption in normal bone remodeling?

Paget's disease is characterized by a disruption in the normal process of bone remodeling, leading to the overgrowth of bone in certain areas. This results in bone that is structurally abnormal and can become enlarged and deformed. The condition often affects the pelvis, skull, spine, and legs, resulting in pain, fractures, and other complications as the bones lose their normal strength and architecture.

Unlike the other conditions listed, Paget's disease specifically involves the alteration of the bone remodeling cycle, which includes both the formation and resorption of bone being altered. This disruption can lead to the formation of new bone that is dense yet weak, ultimately leading to deformities. Osteomyelitis is primarily an infection of the bone, osteogenesis imperfecta is a genetic disorder affecting collagen production leading to brittle bones, and osteitis deformans is actually an older term that can refer to Paget's disease. Therefore, the identification of Paget's disease as the cause of bone deformities due to remodeling disruptions is accurate and highlights the unique pathology associated with this condition.